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Sermorelin
Sermorelin is a bioidentical peptide analog of growth hormone-releasing hormone (GHRH) used in anti-aging and longevity medicine. It stimulates the pituitary gland to naturally increase the production and release of human growth hormone (HGH). Unlike synthetic HGH injections, Sermorelin works upstream to support the body’s own growth hormone rhythm—making it a safer and more physiologically aligned option. It is frequently used to improve body composition, energy, recovery, sleep, skin tone, andcognitive clarity.
How does it work?
Pituitary Stimulation
Sermorelin binds to GHRH receptors in the anterior pituitary, prompting pulsatile HGH secretion, which leads to the downstream production of IGF-1—a key driver of cellular regeneration and repair.
Physiologic vs. Pharmacologic
Because Sermorelin stimulates natural HGH production (rather than replacing it), the body maintains tighter control over hormone levels, reducing the risks associated with supraphysiologic dosing seen with synthetic HGH.
Youthful Restoration
By boosting IGF-1 and HGH, Sermorelin promotes lean muscle gain, fat loss, skin tightening, and improved sleep—restoring multiple markers of youthful function.
Benefits
Stimulates natural HGH production
Improves fat metabolism and muscle tone
Enhances skin elasticity and hydration
Supports deeper, more restorative sleep
Boosts recovery from exercise and injury
Improves focus, mood, and energy
Safer long-term profile compared to exogenous HGH
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