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Sertraline
Sertraline is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat premature ejaculation (PE), one of the most prevalent male sexual health concerns. While originally approved for depression and anxiety, Sertraline has shown effectiveness in delaying ejaculation by increasing serotonin levels in the central nervous system. Used off-label at lower doses than for mood disorders, Sertraline can improve ejaculatory control, sexual confidence, and partner satisfaction—often within days to weeks of use.
How does it work?
Serotonin Enhancement
Sertraline increases serotonin availability in the synaptic cleft. Higher serotonin levels in certain spinal and brain pathways delay the ejaculatory reflex, helping men last longer during intercourse.
Desensitization of Ejaculatory Pathways
Over time, consistent use of Sertraline reduces hypersensitivity in the central nervous system related to ejaculation, allowing men to improve both duration and control during sexual activity.
Mood & Confidence Support
As a secondary benefit, Sertraline may reduce performance anxiety, improve mood, and increase confidence in men affected by PE-related psychological distress.
Benefits
Increases time to ejaculation during sex (2–5x improvement reported)
Can improve control and reduce anxiety associated with sexual performance
Generally well tolerated at low doses used for PE
Non-habit forming
Once-daily oral dosing
Results typically noticeable within 1–2 weeks
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