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PT-141
PT-141 (Bremelanotide) is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousal in both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.
How does it work?
CNS-Based Arousal Enhancement
PT-141 activates melanocortin receptors (MC3R and MC4R) in the hypothalamus, increasing sexual desire and drive by acting on the central nervous system.
Independent of Blood Flow
Unlike PDE5 inhibitors (like sildenafil or tadalafil), PT-141 does not depend on nitric oxide pathways or vascular mechanisms—making it effective for both genders and for arousal-related dysfunction.
Rapid, On-Demand Effect
Administered via subcutaneous injection 45–60 minutes before sexual activity, PT-141 enhances arousal, responsiveness, and sensitivity for several hours.
Benefits
Increases sexual desire in men and women
Effective for psychological and neurological libido issues
Can help men with ED unresponsive to PDE5 inhibitors
Enhances physical arousal, sensation, and orgasmic response
FDA-approved for HSDD in women
Non-hormonal and well tolerated
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